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Details of TopicalPdb ID 1378

PRIMARY INFORMATION
ID1378
PMID21291377
Year2011
SequenceCDLPQTHSLGSRRTLM
LLAQMRKISLFSCLKD
RHDFGFPQEEFGNQFQ
KAETIPVLHEMIQQIF
NLFSTKDSSAAWDETL
LDKFYTELYQQLNDLE
ACVIQGVGVTETPLMK
EDSILAVRKYFQRITL
YLKEKKYSPCAWEVVR
AEIMRSFSLSTNLQES
LRSKE
NameInterferon Alpha (IFN α)
Length165
N-Terminal ModificationFree
C-Terminal ModificationFree
Linear/ CyclicCyclic (C1-C98, C29-138)
ChiralityL
Chemical ModificationGylcosylation at 82th residue
Origin of PeptideInterferon Alpha (IFN α)
Nature of Peptide/CargoAntiviral, antiproliferative, and immunomodulatory properties
MechanismNot mentioned
Cargo Sequence/StructureNone
Name of cargo
Not applicable
AssayELISA and antiviral assay
EnhancerTopical reservoir-type round patches were used for transdermal delivery. Biphasic vesicles preparations with 0, 5, 15, or 40MIU IFN α were placed into the cavity of the patch.
Properties of enhancerNot mentioned
Concentration15 MIU IFN α
Incubation time48 hours
Tissue permeability (value with units)Antiviral assay showed an average IFN α levels of 120±30 IU/mg protein in skin homogenate. ELISA of skin homogenate increased the IFNα levels from <12.5pg/mg tissue to 40.1±12.8 pg/mg tissue.
Tissue SampleHuman skin biopsy samples
Ex vivo/In vivo/In vitroin vivo
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESN.A.