| ID | 1355 | |
| PMID | 1373740 | |
| Year | 1992 | |
| Sequence | TFGSGEADCGLRPLFE KKSLEDKTERELLESY IDGRIVEGSDAEIGMS PWQVMLFRKSPQELLC GASLISDRWVLTAAHC LLYPPWDKNFTENDLL VRIGKHSRTRYERNIE KISMLEKIYIHPRYNW RENLDRDIALMKLKKP VAFSDYIHPVCLPDRE TAASLLQAGYKGRVTG WGNLKETWTANVGKGQ PSVLQVVNLPIVERPV CKDSTRIRITDNMFCA GYKPDEGKRGDACEG | |
| Name | Human α thrombin | |
| Length | 295 | |
| N-Terminal Modification | Free | |
| C-Terminal Modification | Free | |
| Linear/ Cyclic | Linear | |
| Chirality | L | |
| Chemical Modification | None | |
| Origin of Peptide | Synthetic | |
| Nature of Peptide/Cargo | Thromboplastin activation product of prothrombin with high clotting and esterase activity. | |
| Mechanism | They bind thrombin receptors and activate mitogenic signals. | |
| Cargo Sequence/Structure | None | |
| Name of cargo | Not applicable | |
| Assay | Histological examination and numerical scoring of cellular and tissue parameters of wound healing. A 7 day incisional breaking strength was measured. | |
| Enhancer | None | |
| Properties of enhancer | Not applicable | |
| Concentration | 333 ng or 10 pmol/cm | |
| Incubation time | 7 days | |
| Tissue permeability (value with units) | 26% increase in breaking strength, P value of < 0.013, histology demonstrated a more advanced state of healing | |
| Tissue Sample | A single 6-cm vertical incision was made on the dorsal midline or a parallel pair of 6-cm incisions were cut 1.5 cm to either side of the midline of acclimatized adult male Harlan Sprague-Dawley rats. The wound was closed with three simple interrupted sutures placed 1.5cm apart and later received a single peptide dose. | |
| Ex vivo/In vivo/In vitro | in vivo | |
| STRUCTURE |
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| SMILES | N.A. | |