| PRIMARY INFORMATION |
|---|
| ID | 1317 |
| PMID | 2550560 |
| Year | 1989 |
| Sequence | SYSMEHFRWGKPV |
| Name | α-Melanocyte stimulating hormone (MSH) |
| Length | 13 |
| N-Terminal Modification | Acetylation |
| C-Terminal Modification | Amidation |
| Linear/ Cyclic | Linear |
| Chirality | L |
| Chemical Modification | None |
| Origin of Peptide | α-MSH |
| Nature of Peptide/Cargo | It acts as an antagonist to interleukin 1 (IL-1) bioactivities such as inhibition of fever production, thymocyte proliferation, and inhibition of release of acute phase inflammatory molecules from the liver. |
| Mechanism | Epicutaneous application of a-MSH selectively alters the Thy1.2 phenotypic cell marker expression. |
| Cargo Sequence/Structure | None |
Name of cargo
| Not applicable |
| Assay | Indirect immunoperoxidase and indirect immunofluorescence staining |
| Enhancer | On day 6, pineal epidermal specimens were obtained and the population density of la+ Langerhans cells and Thyl+ dendritic epidermal cells in was determined |
| Properties of enhancer | Not mentioned |
| Concentration | 50 µl of 10-5 M α-MSH |
| Incubation time | 5 days |
| Tissue permeability (value with units) | Phenotypic markers: Ia=408 ± 19 , Thy1.2=340 ± 15 and Asialo GM-1=465 ± 18 |
| Tissue Sample | Dorsal surface of the ear of five to seven-wk-old male C57BL/6 (H-2b) mice |
| Ex vivo/In vivo/In vitro | in vivo |
| SECONDARY INFORMATION |
|---|
| STRUCTURE | |
| SMILES | N.A. |
