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Details of TopicalPdb ID 1236

PRIMARY INFORMATION
ID1236
PMID11179600
Year2001
SequencepGlu-HP
NameThyrotropin-releasing hormone (TRH)
Length3
N-Terminal ModificationFree
C-Terminal ModificationAmidation
Linear/ CyclicLinear
ChiralityL
Chemical ModificationpGlu= Pyroglutamic acid
Origin of PeptideSynthetic peptide
Nature of Peptide/CargoTRH has potential clinical value in the treatment of neurotrauma and various neurologic and psychiatric disorders besides its well known endocrinological effects
MechanismNot mentioned
Cargo Sequence/StructureNone
Name of cargo
Not applicable
AssayCardiovascular parameters and blood gas values determined by collecting blood at different time intervals
Enhancer3% cineole and 47% ethanol in PBS
Properties of enhancerIncreases effective penetration of peptide
ConcentrationInitially 100µl of 5 mg/ml of peptide was applied followed by continuous renewal by 50µl/h.
Incubation time120 Minutes
Tissue permeability (value with units)On application of TRH, cardiovascular parameters and blood gas values:Mean arterial blood pressure(kPa)-8.2 ± 0.4, Basal skin blood flow(PU)-244 ± 50, Heart rate(min-1)-359 ± 11, Respiratory rate(min-1)-91 ± 9, pH-7.35 ± 0.02, pCO2(pKa)-6.89 ± 0.33 and pO2(pKa)-10.8 ± 1.55
Tissue SampleStratum corneum of the abdominal area of male Sprague-Dawley rats
Ex vivo/In vivo/In vitroin vivo
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESN.A.