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Details of TopicalPdb ID 1234

PRIMARY INFORMATION
ID1234
PMID11179600
Year2001
SequencepGlu-HP
NameThyrotropin-releasing hormone (TRH)
Length3
N-Terminal ModificationFree
C-Terminal ModificationAmidation
Linear/ CyclicLinear
ChiralityL
Chemical ModificationpGlu= Pyroglutamic acid
Origin of PeptideSynthetic peptide
Nature of Peptide/CargoTRH has potential clinical value in the treatment of neurotrauma and various neurologic and psychiatric disorders besides its well known endocrinological effects
MechanismNot mentioned
Cargo Sequence/StructureNone
Name of cargo
Not applicable
AssayCardiovascular parameters and blood gas values determined by collecting blood at different time intervals
Enhancer3% cineole and 47% ethanol in PBS
Properties of enhancerIncreases effective penetration of peptide
ConcentrationInitially 100µl of 5 mg/ml of peptide was applied followed by continuous renewal by 50µl/h.
Incubation time30 Minutes
Tissue permeability (value with units)On application of TRH, cardiovascular parameters and blood gas values:Mean arterial blood pressure(kPa)-9.9 ± 0.8, Basal skin blood flow(PU)-358 ± 47, Heart rate(min-1)-349 ± 15, Respiratory rate(min-1)-101 ± 5, pH-7.33 ± 0.01, pCO2(pKa)-7.85 ± 0.23 and pO2(pKa)-9.30 ± 0.71
Tissue SampleStratum corneum of the abdominal area of male Sprague-Dawley rats
Ex vivo/In vivo/In vitroin vivo
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESN.A.