| ID | 1216 | |
| PMID | 12932245 | |
| Year | 2003 | |
| Sequence | SVSEIQLMHNLGKHL NSMERVEWLRKKLQD VHNF | |
| Name | Parathyroid Hormone (PTH) | |
| Length | 34 | |
| N-Terminal Modification | Free | |
| C-Terminal Modification | Free | |
| Linear/ Cyclic | Linear | |
| Chirality | L | |
| Chemical Modification | None | |
| Origin of Peptide | Human PTH | |
| Nature of Peptide/Cargo | PTH is an important regulator of calcium and phosphorus metabolism and used for treatment of psoriasis. | |
| Mechanism | Not mentioned | |
| Cargo Sequence/Structure | None | |
| Name of cargo | Not applicable | |
| Assay | Franz cell | |
| Enhancer | Propylene glycol | |
| Properties of enhancer | Not mentioned | |
| Concentration | 1µg PTH | |
| Incubation time | 24h | |
| Tissue permeability (value with units) | <1% PTH dissolved in propylene glycol recovered in the lower chamber of the Franz cell after 24 h | |
| Tissue Sample | Surgically obtained adult abdominal human epidermis | |
| Ex vivo/In vivo/In vitro | in vitro | |
| STRUCTURE |
| |
| SMILES | N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C (=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC (=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O) N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C (=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C (=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C=O)Cc1ccccc1)CC (=O)N)Cc1[nH]cnc1)C(C)C)CC(=O)O)CCC(=O)N)CC(C)C)CCCCN)CCCCN)CCCNC(=N)N)CC(C)C) Cc1c[nH]c2c1cccc2)CCC(=O)O)C(C)C)CCCNC(=N)N)CCC(=O)O)CCSC)CO)CC(=O)N) CC(C)C)Cc1[nH]cnc1)CCCCN)CC(C)C)CC(=O)N)Cc1[nH]cnc1)CCSC)CC(C)C)CCC (=O)N)[C@H](CC)C)CCC(=O)O)CO)C(C)C)CO | |