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Details of TopicalPdb ID 1180

PRIMARY INFORMATION
ID1180
PMID15774286
Year2005
SequenceGEPPPGKPADDAGLV
NamePentadecapeptide BPC157
Length15
N-Terminal ModificationFree
C-Terminal ModificationFree
Linear/ CyclicLinear
ChiralityL
Chemical ModificationNone
Origin of PeptidePartial sequence of the human gastric juice protein BPC
Nature of Peptide/CargoIt consistently improves burn healing, counteract the impairment of burn healing induced by systemic corticosteroids, promotes healing in ulcers and wounds with remarkable stability.
MechanismNot mentioned
Cargo Sequence/StructureNone
Name of cargo
Not applicable
AssayMacroscopically, gross lesion severity was gauged by the depth of the wound crater (mm), the area of necrosis and the wound area. Microscopically, the factors investigated included oedema, blood vessel formation and their total diameter, the number of preserved hair follicles, reticulin and collagen formation.
EnhancerNone
Properties of enhancerNot applicable
Concentration1 ng (dissolved in distilled water)/g commercial neutral cream
Incubation timeOnce daily, with the first application 60 min after injury and the last 24 h before killing for 1 day
Tissue permeability (value with units)Parameters studied: Depth of wound crater(mm)=1.85/2.0(control), Wound necrosis area(mm2)=20/27(control), Wound area(mm2)=97.5/100(control), Oedema (µm)=1100/1175(control), No. of blood vessels=2/2(control), Diameter of blood vessels (µm)=875/1000(control), No. of inflammatory cells=103.5/116(control)
Tissue SampleRandomly assigned male mice (NMRI–Hannover) were used to create an injury on the dorsal skin
Ex vivo/In vivo/In vitroin vivo
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESNCC(=O)N[C@@H](CCC(=O)O)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)
N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCCC[NH3])C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C
(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)
C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C=O