Welcome to Entry Card of Peptide

Details of TopicalPdb ID 1179

PRIMARY INFORMATION
ID	1179
PMID	15774286
Year	2005
Sequence	GEPPPGKPADDAGLV
Name	Pentadecapeptide BPC157
Length	15
N-Terminal Modification	Free
C-Terminal Modification	Free
Linear/ Cyclic	Linear
Chirality	L
Chemical Modification	None
Origin of Peptide	Partial sequence of the human gastric juice protein BPC
Nature of Peptide/Cargo	It consistently improves burn healing, counteract the impairment of burn healing induced by systemic corticosteroids, promotes healing in ulcers and wounds with remarkable stability.
Mechanism	Not mentioned
Cargo Sequence/Structure	None
Name of cargo	Not applicable
Assay	Macroscopically, gross lesion severity was gauged by the depth of the wound crater (mm), the area of necrosis and the wound area. Microscopically, the factors investigated included oedema, blood vessel formation and their total diameter, the number of preserved hair follicles, reticulin and collagen formation.
Enhancer	None
Properties of enhancer	Not applicable
Concentration	1 µg (dissolved in distilled water)/g commercial neutral cream
Incubation time	Once daily, with the first application 60 min after injury and the last 24 h before killing for 1 day
Tissue permeability (value with units)	Parameters studied: Depth of wound crater(mm)=1.35/2.0(control), Wound necrosis area(mm2)=16/27(control), Wound area(mm2)=87.5/100(control), Oedema (µm)=975/1175(control), No. of blood vessels=3/2(control), Diameter of blood vessels (µm)=900/1000(control), No. of inflammatory cells=73.5/116(control)
Tissue Sample	Randomly assigned male mice (NMRI–Hannover) were used to create an injury on the dorsal skin
Ex vivo/In vivo/In vitro	in vivo
SECONDARY INFORMATION
STRUCTURE	Predicted Structure
SMILES	NCC(=O)N[C@@H](CCC(=O)O)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O) N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCCC[NH3])C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C (=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C) C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C=O