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Details of TopicalPdb ID 1173

PRIMARY INFORMATION
ID1173
PMID15906170
Year2005
SequenceWLRRASAPLPGLK
NameP20
Length13
N-Terminal ModificationFree
C-Terminal ModificationFree
Linear/ CyclicLinear
ChiralityL
Chemical ModificationNone
Origin of PeptidePhosphopeptide analogue of the heat shock protein (HSP) 20
Nature of Peptide/CargoPhosphopeptide analogue of the heat shock protein (HSP) 20
MechanismNot mentioned
Cargo Sequence/StructureNone
Name of cargo
Not applicable
AssayFluorimetry analysis using Gemini SpectraMax plate reader
EnhancerNone
Properties of enhancerNone
ConcentrationFITC-labeled peptide is dissolved in phosphate-buffered saline (PBS; 10 mM, pH 7.2) to make peptide concentration 100µM
Incubation time2 Hours
Tissue permeability (value with units)Rate of skin penetration(nmol/cm2/h)- -̴0.13
Tissue SampleFreshly excised porcine ear skin's stratum corneum (facing the donor compartment) was mounted in a Franz diffusion cell
Ex vivo/In vivo/In vitroin vitro
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESN[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC
(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N
[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N1CCC
[C@H]1C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCC[NH3])C=O