Welcome to Entry Card of Peptide


Details of TopicalPdb ID 1113

PRIMARY INFORMATION
ID1113
PMID19733192
Year2010
SequenceGGGARKKAAKAARKK
AAKAARKKAAKAARK
KAAKA
NamePOD-GFP [POD (peptide for ocular delivery)]
Length35
N-Terminal ModificationFree
C-Terminal ModificationFree
Linear/ CyclicLinear
ChiralityL
Chemical ModificationNone
Origin of PeptideNone
Nature of Peptide/CargoCell penetrating peptide
MechanismNot mentioned
Cargo Sequence/StructureMSKGEELFTGVVPVLVELDGDVNGQKFSVSGEGEGDATYGKLTLNFICTTGKLPVPWPTLVTTFSYGVQCFSRYPDHMKQHDFFKSAMPEGYVQERTIFYKDDGNYKTRAEVKFEGDTLVNRIELKGIDFKEDGNILGHKMEYNYNSHNVYIMGDKPKNGIKVNFKIRHNIKDGSVQLADHYQQNTPIGDGPVLLPDNHYLSTQSALSKDPNEKRDHMILLEFVTAARITHGMDELYK
Name of cargo
GFP
AssayFluorescence microscopy
EnhancerNone
Properties of enhancerNot applicable
Concentration40µg
Incubation time24 hours
Tissue permeability (value with units)GFP-fluorescence was 23.4 ±8.8, p < 0.05
Tissue SampleEpidermis of skin of C57BL6/J mice
Ex vivo/In vivo/In vitroin vivo
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESNCC(=O)NCC(=O)NCC(=O)N[C@H](C(=O)N
[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)
N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)
N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H]
(C(=O)N[C@H](C(=O)N[C@H](C(=O)N
[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H]
(C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C
(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H]
(C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C
(=O)N[C@H](C=O)C)CCCCN)C)C)CCCCN)CCCCN)
CCCNC(=N)N)C)C)CCCCN)C)C)CCCCN)CCCCN)CCCNC
(=N)N)C)C)CCCCN)C)C)CCCCN)CCCCN)CCCNC(=N)
N)C)C)CCCCN)C)C)CCCCN)CCCCN)CCCNC(=N)N)C