Welcome to Entry Card of Peptide


Details of TopicalPdb ID 1109

PRIMARY INFORMATION
ID1109
PMID19949052
Year2010
SequenceYTSLIHSLIEESQNQQ
EKNEQELLELDKWAS
LWNWF
NameT20
Length36
N-Terminal ModificationFree
C-Terminal ModificationFree
Linear/ CyclicLinear
ChiralityL
Chemical ModificationNone
Origin of PeptideSynthetic
Nature of Peptide/CargoFusion inhibitor
MechanismInhibits viral genomic integration in intraepithelial vaginal leukocytes
Cargo Sequence/StructureNone
Name of cargo
Not applicable
AssayReal-time PCR
EnhancerNot applicable
Properties of enhancerNot applicable
Concentration200 ng/ml Gag p24 of HIV-1
Incubation time2 hours
Tissue permeability (value with units)Induced a 50% inhibition of HIV-1JRCSF genomic integration in leukocytes residing within the vaginal epithelium (IC50) was 0.153 microM (0.687 ng/ml; 95% confidence interval, 0.563 to 0.84 ng/ml; n=7 independent experiments with 4 donor tissues.
Tissue SampleVaginal epithelial sheet
Ex vivo/In vivo/In vitroex vivo
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESN[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)
N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C
(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C
(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N
[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N
[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N
[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)
N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)
N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C
(=O)N[C@H](C(=O)N[C@H](C=O)Cc1ccccc1)Cc1c[nH]
c2c1cccc2)CC(=O)N)Cc1c[nH]c2c1cccc2)CC(C)C)CO)C)Cc1c
[nH]c2c1cccc2)CCCCN)CC(=O)O)CC(C)C)CCC(=O)O)CC
(C)C)CC(C)C)CCC(=O)O)CCC(=O)N)CCC(=O)O)CC
(=O)N)CCCCN)CCC(=O)O)CCC(=O)N)CCC(=O)N)CC(=O)N)
CCC(=O)N)CO)CCC(=O)O)CCC(=O)O)[C@H](CC)C)
CC(C)C)CO)Cc1[nH]cnc1)[C@H](CC)C)CC(C)C)CO)
[C@H](O)C)Cc1ccc(cc1)O