| ID | 1109 | |
| PMID | 19949052 | |
| Year | 2010 | |
| Sequence | YTSLIHSLIEESQNQQ EKNEQELLELDKWAS LWNWF | |
| Name | T20 | |
| Length | 36 | |
| N-Terminal Modification | Free | |
| C-Terminal Modification | Free | |
| Linear/ Cyclic | Linear | |
| Chirality | L | |
| Chemical Modification | None | |
| Origin of Peptide | Synthetic | |
| Nature of Peptide/Cargo | Fusion inhibitor | |
| Mechanism | Inhibits viral genomic integration in intraepithelial vaginal leukocytes | |
| Cargo Sequence/Structure | None | |
| Name of cargo | Not applicable | |
| Assay | Real-time PCR | |
| Enhancer | Not applicable | |
| Properties of enhancer | Not applicable | |
| Concentration | 200 ng/ml Gag p24 of HIV-1 | |
| Incubation time | 2 hours | |
| Tissue permeability (value with units) | Induced a 50% inhibition of HIV-1JRCSF genomic integration in leukocytes residing within the vaginal epithelium (IC50) was 0.153 microM (0.687 ng/ml; 95% confidence interval, 0.563 to 0.84 ng/ml; n=7 independent experiments with 4 donor tissues. | |
| Tissue Sample | Vaginal epithelial sheet | |
| Ex vivo/In vivo/In vitro | ex vivo | |
| STRUCTURE |
| |
| SMILES | N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O) N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C (=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C (=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N [C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N [C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N [C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O) N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O) N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C (=O)N[C@H](C(=O)N[C@H](C=O)Cc1ccccc1)Cc1c[nH] c2c1cccc2)CC(=O)N)Cc1c[nH]c2c1cccc2)CC(C)C)CO)C)Cc1c [nH]c2c1cccc2)CCCCN)CC(=O)O)CC(C)C)CCC(=O)O)CC (C)C)CC(C)C)CCC(=O)O)CCC(=O)N)CCC(=O)O)CC (=O)N)CCCCN)CCC(=O)O)CCC(=O)N)CCC(=O)N)CC(=O)N) CCC(=O)N)CO)CCC(=O)O)CCC(=O)O)[C@H](CC)C) CC(C)C)CO)Cc1[nH]cnc1)[C@H](CC)C)CC(C)C)CO) [C@H](O)C)Cc1ccc(cc1)O | |