Welcome to TNFepitope

TNF-α is a multifunctional pro-inflammatory cytokine released by T cells or macrophages and control a number of signalling pathways within the immune cells; leads to necrosis or cell death.In the past several studies show that high levels of TNF-α is associated with number of diseases such as autoimmunity, rheumatoid arthritis, diabetes, inflammatory bowel disease, etc. The elevated level of TNF-α, IL-1 and IL-6 causes cytokine release syndrome(CRS) in severe COVID-19 patients. Thus, it is essential to check the existence of TNF-α inducing epitope. Hence, we develop an in-silico tool that allows the user to predict, scan, and map the TNF-α inducing/non-inducing peptides.

Reference: Dhall et al. (2023) TNFepitope: A webserver for the prediction of TNF-α inducing epitopes. Comput Biol Med. doi.org/10.1016/j.compbiomed.2023.106929