Reference: Patiyal S, Singh N, Ali MZ, Pundir DS and Raghava GPS (2022) Sigma70Pred: A highly accurate method for predicting sigma70 promoter in Escherichia coli K-12 strains. Front. Microbiol. 13:1042127. doi: 10.3389/fmicb.2022.1042127.

Welcome to Sigma70Pred

Sigma70Pred is a web-server with the capability of identifying σ70 promoters. Bacterial DNA contains specific nucleotide sequences called promoters that can bind to RNA polymerase. Sigma70 or σ70 is one of the essential promoter sequences which is present in most of the DNA regulatory functions. Under normal conditions, it governs the transcription of most of the housekeeping genes.
We have developed a computation method that is able to predict σ70 promoter by using 200 features from the nucleotide sequences. We have implemented the best performing model for classifying σ70 promoters and non-promoters. σ70Pred significantly exceeds the existing prediction methods.