Biomarker ID | 851 |
PMID | 22298030 |
Year | 2012 |
Biomarker | let-7e |
Biomarker Basis | Expression Based |
Biomolecule | miRNA |
Source | Plasma |
Subjects | Humans |
Regulation | Downregulated in PCa |
Odds Ratio/Hazard Ratio/Relative Risk | NA |
Effect on Pathways | Pathways Include(let-7e):- DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; nuclear lumen; chromatin; nuclear chromosome |
Experiment | prostate cancer Vs benign prostatic hyperplasia |
Type of Biomarker | Diagnostic |
Cohort | Training set: 25 patients with prostate cancer, 17 with Benign prostatic hyperplasia. Validation Set: 80 CaP, 44 BPH, and 54 healthy controls |
Senstivity | 77.78% |
Specificity | 75% |
AUC | 0.804 (95% CI: 0.730–0.878) |
Accuracy | NA |
Level Of Significance | Training: p=0.0029; Testing = p<0.0001 |
Method Used | Training Set: Microarrays, Validation set; qRT-PCR |
Clinical | No |
Remarks | NA |
Clinical Trial Number | NA |
Degree Of Validity | Validated on Independent Patient Cohort |
Technical Name | let-7e |