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Biomarker Card

This biomarker card gives comprehensive information about each biomarker.
Detailed Information
Biomarker ID846
PMID22298030
Year2012
Biomarkerlet-7e
Biomarker BasisExpression Based
BiomoleculemiRNA
SourcePlasma
SubjectsHumans
RegulationDownregulated in PCa
Odds Ratio/Hazard Ratio/Relative RiskNA
Effect on PathwaysPathways Include(let-7e):- DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; nuclear lumen; chromatin; nuclear chromosome
ExperimentProstate Cancer Vs Healthy Men
Type of BiomarkerDiagnostic
CohortTraining set: 25 patients with prostate cancer, 17 with Benign prostatic hyperplasia. Validation Set: 80 CaP, 44 BPH, and 54 healthy controls
Senstivity77.27%
Specificity72.5%
AUC0.805 (95% CI: 0.730–0.881
AccuracyNA
Level Of SignificanceTesting: p<0.001
Method UsedTraining Set: Microarrays, Validation set; qRT-PCR
ClinicalNo
RemarksNA
Clinical Trial NumberNA
Degree Of ValidityValidated on Independent Patient Cohort
Technical Namelet-7e