Biomarker ID | 846 |
PMID | 22298030 |
Year | 2012 |
Biomarker | let-7e |
Biomarker Basis | Expression Based |
Biomolecule | miRNA |
Source | Plasma |
Subjects | Humans |
Regulation | Downregulated in PCa |
Odds Ratio/Hazard Ratio/Relative Risk | NA |
Effect on Pathways | Pathways Include(let-7e):- DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; nuclear lumen; chromatin; nuclear chromosome |
Experiment | Prostate Cancer Vs Healthy Men |
Type of Biomarker | Diagnostic |
Cohort | Training set: 25 patients with prostate cancer, 17 with Benign prostatic hyperplasia. Validation Set: 80 CaP, 44 BPH, and 54 healthy controls |
Senstivity | 77.27% |
Specificity | 72.5% |
AUC | 0.805 (95% CI: 0.730–0.881 |
Accuracy | NA |
Level Of Significance | Testing: p<0.001 |
Method Used | Training Set: Microarrays, Validation set; qRT-PCR |
Clinical | No |
Remarks | NA |
Clinical Trial Number | NA |
Degree Of Validity | Validated on Independent Patient Cohort |
Technical Name | let-7e |