| Biomarker ID | 802 |
| PMID | 22071976 |
| Year | 2011 |
| Biomarker | RNASE2; SLC4A1; HEMGN; CEACAM1; S100P; ALS2; ARG1; SLPI; OLR1; RETN; HBQ1; ALAS2; MMP9; RNASE3; HMGXB4; SELENBP1; GYPE; BPI; TCN1; ORM1; CEACAM6; SNCA; MPO; SNCA; HP; CD24; IFIT1L; EPB42; CTSG; ELA2; PGLYRP1; DEFA1; CEACAM8; HBM; DEFA4; ALAS2; CAMP; LCN2; OLFM4; DEFA3; DEFA1; DEFA1; DEFA1; ERAF; CA1; HBD; DEFA1; |
| Biomarker Basis | Expression Based |
| Biomolecule | mRNA |
| Source | Blood |
| Subjects | Humans |
| Regulation | Upregulated Postvaccine treatment: [RNASE2; SLC4A1; HEMGN; CEACAM1; S100P; ALS2; ARG1; SLPI; OLR1; RETN; HBQ1; ALAS2; MMP9; RNASE3; HMGXB4; SELENBP1; GYPE; BPI; TCN1; ORM1; CEACAM6; SNCA; MPO; HP; CD24; IFIT1L; EPB42; CTSG; ELA2; PGLYRP1; DEFA1; CEACAM8; HBM; DEFA4; CAMP; LCN2; OLFM4; DEFA3; DEFA1;ERAF; CA1; HBD;] |
| Odds Ratio/Hazard Ratio/Relative Risk | NA |
| Effect on Pathways | Pathways Include(ARG1):-Urea cycle,Urea cycle and metabolism of amino groups,Arginine and proline metabolism,ATF2 transcription factor network,Interleukin-4 signaling pathway |
| Experiment | Short Term Survival Pre Vs Post Vaccination |
| Type of Biomarker | Predictive |
| Cohort | 164 patients with metastatic castration-resistant prostate cancer were chosen. Out of which 40 were chosen as control set: (survived for >900 days (long-term survivors n =20) or died within 300 days (short-term survivors n=20). The rest are chosen as validation set. |
| Senstivity | NA |
| Specificity | NA |
| AUC | NA |
| Accuracy | NA |
| Level Of Significance | p< 0.008 |
| Method Used | qRT-PCR |
| Clinical | No |
| Remarks | Personalised Peptide vaccines were given to patients |
| Clinical Trial Number | NA |
| Degree Of Validity | Validated on Independent Patient Cohort |
| Technical Name | RNASE2, SLC4A1, HEMGN, CEACAM1, S100P, ALS2, ARG1, SLPI, OLR1, RETN, HBQ1, ALAS2, MMP9, RNASE3, HMGXB4, SELENBP1, GYPE, BPI, TCN1, ORM1, CEACAM6, SNCA, MPO, HP, CD24, IFIT1L, EPB42, CTSG, ELA2, PGLYRP1, DEFA1, CEACAM8, HBM, DEFA4, CAMP, LCN2, OLFM4, DEFA3, DEFA1, ERAF, CA1, HBD |