| Biomarker ID | 763 |
| PMID | 21963599 |
| Year | 2012 |
| Biomarker | tPSA |
| Biomarker Basis | Concentration Based (ng/ml) |
| Biomolecule | mRNA |
| Source | Serum |
| Subjects | Humans |
| Regulation | Upregulated in Cancerous Conditions (PCA: Median: 7.51; BPH: Median: 4.15) |
| Odds Ratio/Hazard Ratio/Relative Risk | NA |
| Effect on Pathways | Pathways Include :-ID regulation of gene expression,Prostate cancer, Androgen receptor proteolysis and transcription regulation, Androgen receptor signaling, proteolysis, and transcription regulation, Insulin-like growth factor (IGF) activity regulation by insulin-like growth factor binding proteins (IGFBPs) |
| Experiment | Prostate Cancer Vs Benign Prostatic Hyperplasia |
| Type of Biomarker | Diagnostic |
| Cohort | Specimens were obtained from 40 PCa and 30 benign prostate hyperplasia (BPH) patients |
| Senstivity | 90% |
| Specificity | 53.3% |
| AUC | 0.72 |
| Accuracy | 74.3% |
| Level Of Significance | p<0.05 |
| Method Used | NA |
| Clinical | No |
| Remarks | NA |
| Clinical Trial Number | NA |
| Degree Of Validity | Not validated on independent patient dataset |
| Technical Name | KLK3 |