Biomarker ID | 763 |
PMID | 21963599 |
Year | 2012 |
Biomarker | tPSA |
Biomarker Basis | Concentration Based (ng/ml) |
Biomolecule | mRNA |
Source | Serum |
Subjects | Humans |
Regulation | Upregulated in Cancerous Conditions (PCA: Median: 7.51; BPH: Median: 4.15) |
Odds Ratio/Hazard Ratio/Relative Risk | NA |
Effect on Pathways | Pathways Include :-ID regulation of gene expression,Prostate cancer, Androgen receptor proteolysis and transcription regulation, Androgen receptor signaling, proteolysis, and transcription regulation, Insulin-like growth factor (IGF) activity regulation by insulin-like growth factor binding proteins (IGFBPs) |
Experiment | Prostate Cancer Vs Benign Prostatic Hyperplasia |
Type of Biomarker | Diagnostic |
Cohort | Specimens were obtained from 40 PCa and 30 benign prostate hyperplasia (BPH) patients |
Senstivity | 90% |
Specificity | 53.3% |
AUC | 0.72 |
Accuracy | 74.3% |
Level Of Significance | p<0.05 |
Method Used | NA |
Clinical | No |
Remarks | NA |
Clinical Trial Number | NA |
Degree Of Validity | Not validated on independent patient dataset |
Technical Name | KLK3 |