Biomarker ID | 739 |
PMID | 19934327 |
Year | 2009 |
Biomarker | Mutation Status of CLOCK, SNP: rs11133373, G/G + C/G Phenotype |
Biomarker Basis | Mutation Based |
Biomolecule | Mutation |
Source | Blood |
Subjects | Humans |
Regulation | NA |
Odds Ratio/Hazard Ratio/Relative Risk | OR: 0.79 (0.63–0.99) |
Effect on Pathways | Pathways Include:- RORA activates circadian expression,BMAL1-CLOCK/NPAS2 activates circadian expression,Diurnally regulated genes with circadian orthologs, Circadian rhythm,Lipid metabolism regulation by peroxisome proliferator-activated receptor alpha (PPAR-alpha) |
Experiment | Controls Vs More Agressive Disease |
Type of Biomarker | Diagnostic |
Cohort | Total of 1308 patients with Prostate cancer and 1266 patients as controls were used for this study. Out of which 873 were less agressive and 435 were more aggressive. |
Senstivity | NA |
Specificity | NA |
AUC | NA |
Accuracy | NA |
Level Of Significance | p<0.05 |
Method Used | PCR |
Clinical | No |
Remarks | Circadian-related genes were chosen for this study |
Clinical Trial Number | NA |
Degree Of Validity | Not validated on independent patient dataset |
Technical Name | CLOCK |