| Biomarker ID | 734 |
| PMID | 19934327 |
| Year | 2009 |
| Biomarker | Mutation Status of ARNTL, SNP: rs795022; G/A Phenotype |
| Biomarker Basis | Mutation Based |
| Biomolecule | Mutation |
| Source | Blood |
| Subjects | Humans |
| Regulation | NA |
| Odds Ratio/Hazard Ratio/Relative Risk | OR: 1.22 (1.01–1.48) |
| Effect on Pathways | Pathways Include:- RORA activates circadian expression,BMAL1-CLOCK/NPAS2 activates circadian expression,Diurnally regulated genes with circadian orthologs,Circadian rhythm,Hedgehog signaling pathway |
| Experiment | Controls Vs Cancer |
| Type of Biomarker | Diagnostic |
| Cohort | Total of 1308 patients with Prostate cancer and 1266 patients as controls were used for this study. Out of which 873 were less agressive and 435 were more aggressive. |
| Senstivity | NA |
| Specificity | NA |
| AUC | NA |
| Accuracy | NA |
| Level Of Significance | p<0.05 |
| Method Used | PCR |
| Clinical | No |
| Remarks | Circadian-related genes were chosen for this study |
| Clinical Trial Number | NA |
| Degree Of Validity | Not validated on independent patient dataset |
| Technical Name | ARNTL |