Biomarker ID | 728 |
PMID | 19934327 |
Year | 2009 |
Biomarker | Mutation Status of PER2, SNP: rs7602358: T/G+G/G phenotype |
Biomarker Basis | Mutation Based |
Biomolecule | Mutation |
Source | Blood |
Subjects | Humans |
Regulation | NA |
Odds Ratio/Hazard Ratio/Relative Risk | OR: 1.19 (1.00–1.43) |
Effect on Pathways | Pathways Include:-BMAL1-CLOCK/NPAS2 activates circadian expression,Diurnally regulated genes with circadian orthologs,Circadian rhythm, Interleukin-2 signaling pathway |
Experiment | Controls Vs Less Agressive Disease |
Type of Biomarker | Diagnostic |
Cohort | Total of 1308 patients with Prostate cancer and 1266 patients as controls were used for this study. Out of which 873 were less agressive and 435 were more aggressive. |
Senstivity | NA |
Specificity | NA |
AUC | NA |
Accuracy | NA |
Level Of Significance | p<0.05 |
Method Used | PCR |
Clinical | No |
Remarks | Circadian-related genes were chosen for this study |
Clinical Trial Number | NA |
Degree Of Validity | Not validated on independent patient dataset |
Technical Name | PER2 |