| Biomarker ID | 723 |
| PMID | 19755651 |
| Year | 2009 |
| Biomarker | Methylation Status of GST-Pi |
| Biomarker Basis | Methylation Based |
| Biomolecule | Methylation |
| Source | Tissue |
| Subjects | Humans |
| Regulation | Hypermethylated in PCa |
| Odds Ratio/Hazard Ratio/Relative Risk | NA |
| Effect on Pathways | Pathways include: Biological oxidations, Metapathway biotransformation, Pathways in cancer, T cell receptor regulation of apoptosis, Metabolism |
| Experiment | negative histology followed by a positive biopsy less than 24 months later |
| Type of Biomarker | Diagnostic |
| Cohort | 450 patients were analysed. Negative histology followed by a negative biopsy less than 24 months later (n=164); negative histology followed by a positive biopsy less than 24 months later (n= 170) and first positive biopsy (n=116). A total of 264 patients were then selected for the study. |
| Senstivity | neg/pos = 52%; pos = 95% |
| Specificity | pos/pos = 85% |
| AUC | 0.683 |
| Accuracy | NA |
| Level Of Significance | NA |
| Method Used | quantitative methylation-specific PCR |
| Clinical | No |
| Remarks | Negative histology followed by a negative biopsy less than 24 months later (neg/neg); negative histology followed by a positive biopsy less than 24 months later (neg/pos) and first positive biopsy (pos). |
| Clinical Trial Number | NA |
| Degree Of Validity | Not validated on independent patient dataset |
| Technical Name | GSTP1 |