Biomarker ID | 713 |
PMID | 21894431 |
Year | 2011 |
Biomarker | α2-macroglobulin (α2M) |
Biomarker Basis | Concentration Based (mg/dl) |
Biomolecule | Protein |
Source | Serum |
Subjects | Humans |
Regulation | Downregulated with α2M deficiency (Without α2M deficiency: 252.45±125.07 Vs with α2M deficiency: 12.75±5.60) |
Odds Ratio/Hazard Ratio/Relative Risk | NA |
Effect on Pathways | Pathways Include:- Prothrombin activation intrinsic pathway, Coagulation intrinsic pathway, Fibrin clot formation (clotting cascade), Lipid digestion, mobilization, and transport, Interleukin-6 signaling pathway |
Experiment | PCa patients without α2M deficiency vs. PCa patients with α2M deficiency |
Type of Biomarker | Prognostic |
Cohort | 43 untreated adult men participated in this study, of whom 10 were healthy controls (mean age 62.8 years, range 52-70) and 33 were diagnosed with prostatic disease. Out of those with prostate cancer- Without α2M deficiency (n=23) and with α2M deficiency (n=10). |
Senstivity | NA |
Specificity | NA |
AUC | NA |
Accuracy | NA |
Level Of Significance | p<0.01 |
Method Used | Western blot |
Clinical | No |
Remarks | NA |
Clinical Trial Number | NA |
Degree Of Validity | Not validated on independent patient dataset |
Technical Name | A2M |