| Biomarker ID | 70 |
| PMID | 15645116 |
| Year | 2005 |
| Biomarker | AMACR (o-methylacyl-CoA racemaÌŠse) |
| Biomarker Basis | Expression Based |
| Biomolecule | mRNA |
| Source | Tissue |
| Subjects | Humans |
| Regulation | Upregulated in PCa (3.3 fold) |
| Odds Ratio/Hazard Ratio/Relative Risk | NA |
| Effect on Pathways | Pathways Include:-Primary bile acid biosynthesis,Bile acids and bile salt biosynthesis,Peroxisomal lipid metabolism,Bile acid and bile salt biosynthesis via 7-alpha-hydroxycholesterol,Bile acid and bile salt metabolism |
| Experiment | Malignant Vs Benign Tissue |
| Type of Biomarker | Diagnostic |
| Cohort | Samples were collected from 33 patients. 52 specimens were obtained, out of which 19 were paired malignant and benign, 29 were primary tumors and 4 benign tissue samples |
| Senstivity | NA |
| Specificity | NA |
| AUC | NA |
| Accuracy | NA |
| Level Of Significance | p<0.05 |
| Method Used | Microarray Analysis |
| Clinical | No |
| Remarks | AMACR Validated by qPCR results. Upon analysis, 51 genes were found which were differentially expressed. 30 top genes were taken on the basis of there t-test scores and leave one out cross validation was performed with Fischer's Linear Discrimant and 90.3% accuracy was achieved while discriminating between Tumor (T) And Benign (B) Samples. |
| Clinical Trial Number | NA |
| Degree Of Validity | Validated on independent patient dataset |
| Technical Name | AMACR |