Biomarker Card
This biomarker card gives comprehensive information about each biomarker.
| Detailed Information | |
|---|---|
| Biomarker ID | 635 |
| PMID | 21504557 |
| Year | 2011 |
| Biomarker | PSA |
| Biomarker Basis | Expression Based |
| Biomolecule | Protein |
| Source | Serum |
| Subjects | Humans |
| Regulation | Upregulated in PCa |
| Odds Ratio/Hazard Ratio/Relative Risk | NA |
| Effect on Pathways | Pathways include:-ID regulation of gene expression,Prostate cancer, Androgen receptor proteolysis and transcription regulation, Androgen receptor signaling, proteolysis, and transcription regulation, Insulin-like growth factor (IGF) activity regulation by insulin-like growth factor binding proteins (IGFBPs) |
| Experiment | Prostate Cancer Vs BPH |
| Type of Biomarker | Diagnostic |
| Cohort | A total of 124 healthy donors along with 121 patients with BPH (or Prostatis) and 131 patients with prostate cancer were chosen for the study. |
| Senstivity | 52% (68/131) |
| Specificity | 79% (95/121) |
| AUC | 0.66 |
| Accuracy | 65% |
| Level Of Significance | p<0.05 |
| Method Used | SeroMAP-based assays and ELISA |
| Clinical | No |
| Remarks | NA |
| Clinical Trial Number | NA |
| Degree Of Validity | Not validated on independent patient dataset |
| Technical Name | KLK3 |