| Biomarker ID | 624 |
| PMID | 21467234 |
| Year | 2011 |
| Biomarker | Mutation Status of TNFSF10 (SNP: rs3774315 (A/G)) |
| Biomarker Basis | Mutation Based |
| Biomolecule | Mutation |
| Source | Blood |
| Subjects | Humans |
| Regulation | Associated with Disease Aggressiveness |
| Odds Ratio/Hazard Ratio/Relative Risk | OR: Discovery Set: 2.5 (95% CI: 1.55–4.03); Testing Set: 1.25 (95% CI: 1.08–1.46) |
| Effect on Pathways | Pathways Include:- TP53 network, Death receptor signaling, Induction of apoptosis through DR3 and DR4/5 death receptors, TRAIL signaling pathway, Activation of pro-caspase 8 |
| Experiment | Less Aggressive Vs Controls |
| Type of Biomarker | Diagnostic |
| Cohort | For the discovery set, 100 controls along with 202 patients with aggressive disease were taken for the study. In the test set, 1167 controls along with 527 patients with Less aggressive disease and 595 patients with more aggressive disease were chosen for the study. |
| Senstivity | NA |
| Specificity | NA |
| AUC | NA |
| Accuracy | NA |
| Level Of Significance | Discovery Set: 0.0000734; Testing Set: p=0.002 |
| Method Used | Affy- metrix Human Mapping 500K array |
| Clinical | No |
| Remarks | NA |
| Clinical Trial Number | NA |
| Degree Of Validity | Validated on Independent Patient Dataset |
| Technical Name | TNFSF10 |