| Biomarker ID | 621 |
| PMID | 21467234 |
| Year | 2011 |
| Biomarker | Mutation Status of WWOX (SNP: rs11150069 (C/A)) |
| Biomarker Basis | Mutation Based |
| Biomolecule | Mutation |
| Source | Blood |
| Subjects | Humans |
| Regulation | Associated with Disease Aggressiveness |
| Odds Ratio/Hazard Ratio/Relative Risk | OR: Discovery Set: 0.42 (95% CI: 0.28–0.62); |
| Effect on Pathways | Pathways Include:-ERBB4 signaling events, Nuclear signaling by ErbB4, p73 transcription factor network, Signaling by ERBB4 |
| Experiment | More Aggressive Vs Controls |
| Type of Biomarker | Diagnostic |
| Cohort | For the discovery set, 100 controls along with 202 patients with aggressive disease were taken for the study. In the test set, 1167 controls along with 527 patients with Less aggressive disease and 595 patients with more aggressive disease were chosen for the study. |
| Senstivity | NA |
| Specificity | NA |
| AUC | NA |
| Accuracy | NA |
| Level Of Significance | Discovery Set: p= 0.00000943 |
| Method Used | Affy- metrix Human Mapping 500K array |
| Clinical | No |
| Remarks | NA |
| Clinical Trial Number | NA |
| Degree Of Validity | Validated on Independent Patient Dataset |
| Technical Name | WWOX |