| Biomarker ID | 607 |
| PMID | 21400514 |
| Year | 2011 |
| Biomarker | let-7a; miR-101; miR-106a; miR-106b; miR-1274; miR-141; miR-17; miR-182; miR-1826; miR-200b; miR-200c; miR-20a; miR-20b; miR-21; miR-375; miR-720; miR-768-3p; miR-93 |
| Biomarker Basis | Expression Based |
| Biomolecule | miRNA |
| Source | Tissue |
| Subjects | Humans |
| Regulation | Upregulated in PCa(Fold Change): let-7a(1.53 fold) ; miR-101(1.13 fold) ; miR-106a(2.41 fold); miR-106b(1.70 fold); miR-1274(1.87 fold); miR-141(1.44 fold); miR-17(2.69 fold); miR-182(2.39 fold) ; miR-1826(1.73 fold) ; miR-200b( 1.54 fold) ; miR-200c( 2.92 fold); miR-20a(2.67 fold); miR-20b(2.81 fold); miR-21( 1.40 fold); miR-375(3.90 fold) ; miR-720(1.41 fold); miR-768-3p(1.67 fold); miR-93(2.52 fold) |
| Odds Ratio/Hazard Ratio/Relative Risk | NA |
| Effect on Pathways | Pathways Include(let-7a):- nucleoplasm; regulation of RNA metabolic process; DNA-binding transcription factor activity, RNA polymerase II-specific; regulation of nucleic acid-templated transcriptionregulation of transcription, DNA-templatedPathways Include(miR-101):- DNA binding; Gene expression (Transcription); Generic Transcription Pathway; RNA Polymerase II Transcription; DNA-binding transcription factor activity, RNA polymerase II-specific Pathways Include(miR-106a):- DNA-binding transcription factor activity, RNA polymerase II-specific ;Gene expression (Transcription); RNA Polymerase II Transcription; Generic Transcription Pathway; DNA-binding transcription factor activity Pathways Include(miRNA-141):- regulation of RNA metabolic process; Gene expression (Transcription); RNA Polymerase II Transcription; nuclear chromosome; DNA-binding transcription factor activity, RNA polymerase II-specific |
| Experiment | Prostate Cancer Vs Normal |
| Type of Biomarker | Diagnostic |
| Cohort | 20 matched tumor and normal tissue samples were measured. |
| Senstivity | NA |
| Specificity | NA |
| AUC | NA |
| Accuracy | NA |
| Level Of Significance | p<0.001 |
| Method Used | MiRNA microarrays |
| Clinical | No |
| Remarks | NA |
| Clinical Trial Number | NA |
| Degree Of Validity | Validated on Independent Patient Dataset |
| Technical Name | let-7a, miR-101, miR-106a, miR-106b, miR-1274, miR-141, miR-17, miR-182, miR-1826, miR-200b, miR-200c, miR-20a, miR-20b, miR-21, miR-375, miR-720, miR-768-3p, miR-93 |