| Biomarker ID | 576 |
| PMID | 21166384 |
| Year | 2011 |
| Biomarker | Protein AMBP; Haptoglobin (R chain) ; Pigment Epithelium-Derived Factor 207 Kininogen-1 |
| Biomarker Basis | Expression Based |
| Biomolecule | Protein |
| Source | Serum |
| Subjects | Humans |
| Regulation | Downregulated in Non Organ Confined: [Haptoglobin (R chain) ]; Upregulated in Non Organ Confined: [Protein AMBP; Pigment Epithelium-Derived Factor 207 Kininogen-1] |
| Odds Ratio/Hazard Ratio/Relative Risk | NA |
| Effect on Pathways | Pathways Include(AMBP):-Binding and Uptake of Ligands by Scavenger Receptors,Vesicle-mediated transport,Cell adhesion_Cell-matrix glycoconjugates,Scavenging of heme from plasma Pathways Include(HP):-Oncostatin M |
| Experiment | Organ Confined vs Non-Organ Confined |
| Type of Biomarker | Prognostic |
| Cohort | Out of total 50 patients, 18 with GS 5, 18 with GS 7 and 14 with BPH were identified. |
| Senstivity | NA |
| Specificity | NA |
| AUC | 0.856 |
| Accuracy | NA |
| Level Of Significance | NA |
| Method Used | 2D-gel Electrophoresis |
| Clinical | No |
| Remarks | Random forest technique was applied to find a biomarker panel for 59 differentiated protiens. Data shown for 10 fold cross validation. Improves performance over PSA (AUC= 0.617) |
| Clinical Trial Number | NA |
| Degree Of Validity | Not validated on independent patient dataset |
| Technical Name | AMBP, HP, KNG1 |