Biomarker ID | 566 |
PMID | 21074193 |
Year | 2011 |
Biomarker | DKK1 (Dickkopf-1) |
Biomarker Basis | Expression Based |
Biomolecule | Protein |
Source | Serum |
Subjects | Humans |
Regulation | Upregulated in PCa |
Odds Ratio/Hazard Ratio/Relative Risk | NA |
Effect on Pathways | Pathways Include:- Wnt/LRP6 signaling,Inactivation of GSK3 by Akt causes accumulation of beta-catenin in alveolar macrophages,Presenilin action in Notch and Wnt signaling,Wnt interactions in lipid metabolism and immune response,Multi-step regulation of transcription by PITX2 |
Experiment | Control Vs Cancer |
Type of Biomarker | Diagnostic |
Cohort | 250 prostate cancer patients from SABOR cohort were taken and 250 controls with matched age and ethnicity were taken |
Senstivity | 5% |
Specificity | 95% |
AUC | 0.53 (0.48, 0.58) |
Accuracy | NA |
Level Of Significance | p<0.05 |
Method Used | ELISA |
Clinical | No |
Remarks | Results shown for 70,80, 90 and 95% Specificity |
Clinical Trial Number | NA |
Degree Of Validity | Not validated on independent patient dataset |
Technical Name | DKK1 |