| Biomarker ID | 566 |
| PMID | 21074193 |
| Year | 2011 |
| Biomarker | DKK1 (Dickkopf-1) |
| Biomarker Basis | Expression Based |
| Biomolecule | Protein |
| Source | Serum |
| Subjects | Humans |
| Regulation | Upregulated in PCa |
| Odds Ratio/Hazard Ratio/Relative Risk | NA |
| Effect on Pathways | Pathways Include:- Wnt/LRP6 signaling,Inactivation of GSK3 by Akt causes accumulation of beta-catenin in alveolar macrophages,Presenilin action in Notch and Wnt signaling,Wnt interactions in lipid metabolism and immune response,Multi-step regulation of transcription by PITX2 |
| Experiment | Control Vs Cancer |
| Type of Biomarker | Diagnostic |
| Cohort | 250 prostate cancer patients from SABOR cohort were taken and 250 controls with matched age and ethnicity were taken |
| Senstivity | 5% |
| Specificity | 95% |
| AUC | 0.53 (0.48, 0.58) |
| Accuracy | NA |
| Level Of Significance | p<0.05 |
| Method Used | ELISA |
| Clinical | No |
| Remarks | Results shown for 70,80, 90 and 95% Specificity |
| Clinical Trial Number | NA |
| Degree Of Validity | Not validated on independent patient dataset |
| Technical Name | DKK1 |