| Biomarker ID | 565 |
| PMID | 21074193 |
| Year | 2011 |
| Biomarker | %fPSA (%free prostate specific antigen) |
| Biomarker Basis | Expression Based |
| Biomolecule | Protein |
| Source | Serum |
| Subjects | Humans |
| Regulation | Downregulated in PCa |
| Odds Ratio/Hazard Ratio/Relative Risk | NA |
| Effect on Pathways | Pathways include:-ID regulation of gene expression,Prostate cancer, Androgen receptor proteolysis and transcription regulation, Androgen receptor signaling, proteolysis, and transcription regulation, Insulin-like growth factor (IGF) activity regulation by insulin-like growth factor binding proteins (IGFBPs) |
| Experiment | Control Vs Cancer |
| Type of Biomarker | Diagnostic |
| Cohort | 250 prostate cancer patients from SABOR cohort were taken and 250 controls with matched age and ethnicity were taken |
| Senstivity | 34% |
| Specificity | 95% |
| AUC | 0.76 (95% CI: 0.72- 0.8) |
| Accuracy | NA |
| Level Of Significance | p<0.05 |
| Method Used | ELISA |
| Clinical | No |
| Remarks | Results shown for 70,80, 90 and 95% Specificity |
| Clinical Trial Number | NA |
| Degree Of Validity | Not validated on independent patient dataset |
| Technical Name | KLK3 |