Biomarker ID | 564 |
PMID | 21074193 |
Year | 2011 |
Biomarker | [-2]proPSA ([-2]proenzyme prostate specific antigen) |
Biomarker Basis | Expression Based |
Biomolecule | Protein |
Source | Serum |
Subjects | Humans |
Regulation | Upregulated in PCa |
Odds Ratio/Hazard Ratio/Relative Risk | NA |
Effect on Pathways | Pathways include:-ID regulation of gene expression,Prostate cancer, Androgen receptor proteolysis and transcription regulation, Androgen receptor signaling, proteolysis, and transcription regulation, Insulin-like growth factor (IGF) activity regulation by insulin-like growth factor binding proteins (IGFBPs) |
Experiment | Control Vs Cancer |
Type of Biomarker | Diagnostic |
Cohort | 250 prostate cancer patients from SABOR cohort were taken and 250 controls with matched age and ethnicity were taken |
Senstivity | 0.16% |
Specificity | 95% |
AUC | 0.72 (95% CI: 0.67- 0.76) |
Accuracy | NA |
Level Of Significance | p<0.05 |
Method Used | ELISA |
Clinical | No |
Remarks | Results shown for 70,80, 90 and 95% Specificity |
Clinical Trial Number | NA |
Degree Of Validity | Not validated on independent patient dataset |
Technical Name | KLK3 |