| Biomarker ID | 560 |
| PMID | 20977276 |
| Year | 2011 |
| Biomarker | Lamin A |
| Biomarker Basis | Expression Based |
| Biomolecule | Protein |
| Source | Tissue |
| Subjects | Humans |
| Regulation | Upregulated in GS 8 and above |
| Odds Ratio/Hazard Ratio/Relative Risk | NA |
| Effect on Pathways | Pathways Include:- Caspase cascade in apoptosis,Meiosis,Unfolded protein response,Chromosome maintenance,HIV-1 Nef as negative effector of Fas and TNF |
| Experiment | Gleason Score 6 Vs Gleason Score 8 and above |
| Type of Biomarker | Prognostic |
| Cohort | 46 patients were chosen for the study such that 23 had a gleason score of 6 and 23 had a score of 8 or higher. Validation set: Tissue cores of 94 tumor cases (3 tumor and 1 benign cores of each case) was taken for validation set. |
| Senstivity | NA |
| Specificity | NA |
| AUC | 0.88 |
| Accuracy | NA |
| Level Of Significance | p<0.05 |
| Method Used | Immunohistochemistry |
| Clinical | No |
| Remarks | NA |
| Clinical Trial Number | NA |
| Degree Of Validity | Validated on Independent Patient Dataset |
| Technical Name | LMNA |