Biomarker ID | 537 |
PMID | 20632874 |
Year | 2010 |
Biomarker | AR: (Short CAG) |
Biomarker Basis | Mutation Based |
Biomolecule | Mutation |
Source | Blood |
Subjects | Humans |
Regulation | Increased RIsk of GS (4+3) with Short CAG Repeats |
Odds Ratio/Hazard Ratio/Relative Risk | OR: 8.8 (95% CI:1.06–73.05) |
Effect on Pathways | Pathways Include:- Prostate cancer,Androgen receptor signaling, proteolysis, and transcription regulation,SMAD2/3 nuclear pathway,Oocyte meiosis,SIDS susceptibility pathways |
Experiment | Gleason Score 7 (4+3) Vs Gleason Score 7 (3+4) |
Type of Biomarker | Prognostic |
Cohort | 170 patients who underwent radical prosteactomy were taken for this study along with 170 controls. 82 had Gleason Score >=7 and 88 have gleason Score <7. |
Senstivity | NA |
Specificity | NA |
AUC | NA |
Accuracy | NA |
Level Of Significance | p = 0.045 |
Method Used | PCR-RFLP (restriction fragment length polymorphism) |
Clinical | No |
Remarks | NA |
Clinical Trial Number | NA |
Degree Of Validity | Not validated on independent patient dataset |
Technical Name | AR |