| Biomarker ID | 536 |
| PMID | 20632874 |
| Year | 2010 |
| Biomarker | PSA (G/G Genotype) |
| Biomarker Basis | Mutation Based |
| Biomolecule | Mutation |
| Source | Blood |
| Subjects | Humans |
| Regulation | Increases risk of Gleason Score >=7 with G/G Genotype compared with the G/A & A/A genotype |
| Odds Ratio/Hazard Ratio/Relative Risk | OR: 2.54 (95% CI: 1.27–5.07) |
| Effect on Pathways | Pathways include:-ID regulation of gene expression,Prostate cancer, Androgen receptor proteolysis and transcription regulation, Androgen receptor signaling, proteolysis, and transcription regulation, Insulin-like growth factor (IGF) activity regulation by insulin-like growth factor binding proteins (IGFBPs) |
| Experiment | Gleason ≤7 Vs Gleason Score >7 |
| Type of Biomarker | Prognostic |
| Cohort | 170 patients who underwent radical prosteactomy were taken for this study along with 170 controls. 82 had Gleason Score >=7 and 88 have gleason Score <7. |
| Senstivity | NA |
| Specificity | NA |
| AUC | NA |
| Accuracy | NA |
| Level Of Significance | p= 0.0122 |
| Method Used | PCR-RFLP (restriction fragment length polymorphism) |
| Clinical | No |
| Remarks | NA |
| Clinical Trial Number | NA |
| Degree Of Validity | Not validated on independent patient dataset |
| Technical Name | KLK3 |