Biomarker Card
This biomarker card gives comprehensive information about each biomarker.
| Detailed Information | |
|---|---|
| Biomarker ID | 535 |
| PMID | 20632874 |
| Year | 2010 |
| Biomarker | PSA and AR (G/G and Short CAG) |
| Biomarker Basis | Mutation Based |
| Biomolecule | Mutation |
| Source | Blood |
| Subjects | Humans |
| Regulation | Increased Risk of Prostate Cancer |
| Odds Ratio/Hazard Ratio/Relative Risk | 2.02 (1.07–3.82 |
| Effect on Pathways | Pathways Include(KLK3):-ID regulation of gene expression,Prostate cancer, Androgen receptor proteolysis and transcription regulation, Androgen receptor signaling, proteolysis, and transcription regulation, Insulin-like growth factor (IGF) activity regulation by insulin-like growth factor binding proteins (IGFBPs) Pathways Include(AR):- Pathways Include:- Prostate cancer,Androgen receptor signaling, proteolysis, and transcription regulation,SMAD2/3 nuclear pathway,Oocyte meiosis,SIDS susceptibility pathways |
| Experiment | Cancer Vs Controls |
| Type of Biomarker | Diagnostic |
| Cohort | 160 patients who underwent radical prosteactomy were taken for this study along with 160 controls. |
| Senstivity | NA |
| Specificity | NA |
| AUC | NA |
| Accuracy | NA |
| Level Of Significance | p = 0.0418 |
| Method Used | PCR-RFLP (restriction fragment length polymorphism) |
| Clinical | No |
| Remarks | NA |
| Clinical Trial Number | NA |
| Degree Of Validity | Not validated on independent patient dataset |
| Technical Name | KLK3, AR |