Biomarker Card
This biomarker card gives comprehensive information about each biomarker.
Detailed Information | |
---|---|
Biomarker ID | 535 |
PMID | 20632874 |
Year | 2010 |
Biomarker | PSA and AR (G/G and Short CAG) |
Biomarker Basis | Mutation Based |
Biomolecule | Mutation |
Source | Blood |
Subjects | Humans |
Regulation | Increased Risk of Prostate Cancer |
Odds Ratio/Hazard Ratio/Relative Risk | 2.02 (1.07–3.82 |
Effect on Pathways | Pathways Include(KLK3):-ID regulation of gene expression,Prostate cancer, Androgen receptor proteolysis and transcription regulation, Androgen receptor signaling, proteolysis, and transcription regulation, Insulin-like growth factor (IGF) activity regulation by insulin-like growth factor binding proteins (IGFBPs) Pathways Include(AR):- Pathways Include:- Prostate cancer,Androgen receptor signaling, proteolysis, and transcription regulation,SMAD2/3 nuclear pathway,Oocyte meiosis,SIDS susceptibility pathways |
Experiment | Cancer Vs Controls |
Type of Biomarker | Diagnostic |
Cohort | 160 patients who underwent radical prosteactomy were taken for this study along with 160 controls. |
Senstivity | NA |
Specificity | NA |
AUC | NA |
Accuracy | NA |
Level Of Significance | p = 0.0418 |
Method Used | PCR-RFLP (restriction fragment length polymorphism) |
Clinical | No |
Remarks | NA |
Clinical Trial Number | NA |
Degree Of Validity | Not validated on independent patient dataset |
Technical Name | KLK3, AR |