Biomarker ID | 514 |
PMID | 20087897 |
Year | 2010 |
Biomarker | Enhancer of Zeste 2 (EZH2) |
Biomarker Basis | Expression Based |
Biomolecule | mRNA |
Source | Cell Lines |
Subjects | Humans |
Regulation | Overexpression leads to aggressive behaviour in Cell Lines |
Odds Ratio/Hazard Ratio/Relative Risk | NA |
Effect on Pathways | Pathways Include:- Cell differentiation pathway,MicroRNAs in muscle cell differentiation, PRC2 complex long-term gene silencing through modification of histone tails,Interleukin-2 signaling pathway |
Experiment | Overexpression Vs No Overexpression in Cell Lines |
Type of Biomarker | Prognostic |
Cohort | 5 cell lines were used BPH1, CWR22Rv1, PC3, DU145, and LNCaP for the experiment. |
Senstivity | NA |
Specificity | NA |
AUC | NA |
Accuracy | NA |
Level Of Significance | NA |
Method Used | qRT-PCR |
Clinical | No |
Remarks | NA |
Clinical Trial Number | NA |
Degree Of Validity | Not validated on independent patient dataset |
Technical Name | EZH2 |