| Biomarker ID | 508 |
| PMID | 20043080 |
| Year | 2010 |
| Biomarker | TRPM8 (transient receptor potential member 8) |
| Biomarker Basis | Expression Based |
| Biomolecule | mRNA |
| Source | Tissue |
| Subjects | Humans |
| Regulation | Upregulated in PCa (ratio = 1.94±0.256) |
| Odds Ratio/Hazard Ratio/Relative Risk | NA |
| Effect on Pathways | Pathways Include:- Ion channel transport; Development Endothelin-1/EDNRA signaling;CREB Pathway; Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds;TRP channels |
| Experiment | Tumors Vs patient matched non-tumor |
| Type of Biomarker | Diagnostic |
| Cohort | Tumor and patient-matched non-tumor tissue RNA from 40 patients with Gleason scores ranging from 6 to 9 |
| Senstivity | NA |
| Specificity | NA |
| AUC | NA |
| Accuracy | NA |
| Level Of Significance | p<0.01 |
| Method Used | Semi Quantative RT-PCR |
| Clinical | No |
| Remarks | TRPM8 levels were expressed as a ratio of TRPM8/AR mRNA levels |
| Clinical Trial Number | NA |
| Degree Of Validity | Validated on independent patient dataset |
| Technical Name | TRPM8 |