Biomarker ID | 508 |
PMID | 20043080 |
Year | 2010 |
Biomarker | TRPM8 (transient receptor potential member 8) |
Biomarker Basis | Expression Based |
Biomolecule | mRNA |
Source | Tissue |
Subjects | Humans |
Regulation | Upregulated in PCa (ratio = 1.94±0.256) |
Odds Ratio/Hazard Ratio/Relative Risk | NA |
Effect on Pathways | Pathways Include:- Ion channel transport; Development Endothelin-1/EDNRA signaling;CREB Pathway; Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds;TRP channels |
Experiment | Tumors Vs patient matched non-tumor |
Type of Biomarker | Diagnostic |
Cohort | Tumor and patient-matched non-tumor tissue RNA from 40 patients with Gleason scores ranging from 6 to 9 |
Senstivity | NA |
Specificity | NA |
AUC | NA |
Accuracy | NA |
Level Of Significance | p<0.01 |
Method Used | Semi Quantative RT-PCR |
Clinical | No |
Remarks | TRPM8 levels were expressed as a ratio of TRPM8/AR mRNA levels |
Clinical Trial Number | NA |
Degree Of Validity | Validated on independent patient dataset |
Technical Name | TRPM8 |