| Biomarker ID | 495 |
| PMID | 19894759 |
| Year | 2009 |
| Biomarker | keratin 5; mutant desmin; histone cluster 2, H2bf; |
| Biomarker Basis | Expression Based |
| Biomolecule | Protein |
| Source | Tissue |
| Subjects | Humans |
| Regulation | Downregulated ratio in Localised PCA: keratin 5 [2.08]; mutant desmin [2.03]; histone cluster 2, H2bf [2.02]; |
| Odds Ratio/Hazard Ratio/Relative Risk | NA |
| Effect on Pathways | NA |
| Experiment | Localized PCa and BPH |
| Type of Biomarker | Diagnostic |
| Cohort | 17 cases of PCa who underwent radical prostatectomy and standard bilateral lymphadenectomy and 10 cases of benign prostatic hyperplasia (BPH) were collected. The PCa samples were divided into two groups of localized PCa (N ) 10) and LNM PCa (N ) 7) according to the postoperative pathological examinations of pelvic lymph nodes |
| Senstivity | NA |
| Specificity | NA |
| AUC | NA |
| Accuracy | NA |
| Level Of Significance | p<0.05 |
| Method Used | 2-D DIGE coupled with MALDI-TOF/TOF MS |
| Clinical | No |
| Remarks | NA |
| Clinical Trial Number | NA |
| Degree Of Validity | Validated on Independent Patient Dataset |
| Technical Name | KRT5: DES: H2BC18 |