| Biomarker ID | 474 |
| PMID | 19652763 |
| Year | 2009 |
| Biomarker | CCNB1 (cyclin B1); CENPF (centromere protein F, 350/400 ka (mitosin)); BUB1B (BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast)); CLDN4 (claudin 4); KIAA0101 (KIAA0101); LOC400879 (Hypothetical gene supported by AK096951); SLC39A6 (solute carrier family 39 (zinc transporter), member 6); SOX4 (SRY (sex determining region Y)-box 4); TOP2A (topoisomerase (DNA) II alpha 170 kDa) |
| Biomarker Basis | Expression Based |
| Biomolecule | mRNA |
| Source | Tissue |
| Subjects | Humans |
| Regulation | Upregulated: CCNB1 (cyclin B1) [1.8 fold]; CENPF (centromere protein F, 350/400 ka (mitosin)) [1.4 fold]; BUB1B (BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast)) [1.4 fold]; CLDN4 (claudin 4) [2.4 fold]; KIAA0101 (KIAA0101) [1.6 fold]; LOC400879 (Hypothetical gene supported by AK096951) [1.7 fold]; SLC39A6 (solute carrier family 39 (zinc transporter), member 6) [1.6 fold]; SOX4 (SRY (sex determining region Y)-box 4) [1.8 fold]; TOP2A (topoisomerase (DNA) II alpha 170 kDa) [1.7 fold] |
| Odds Ratio/Hazard Ratio/Relative Risk | NA |
| Effect on Pathways | Pathways include (CCNB1): T cell receptor regulation of apoptosis, Cell cycle, Oncostatin M, Chk1/Chk2(Cds1)-mediated inactivation of cyclin B-Cdk1 complex, p53 signaling pathway |
| Experiment | Tumor Vs Adjacent To Tumor |
| Type of Biomarker | Diagnostic |
| Cohort | 148 patients such as 23 were organ donors, 59 adjacent to Tumor, and 66 Tumor samples were included. |
| Senstivity | NA |
| Specificity | NA |
| AUC | NA |
| Accuracy | Validation Set: 93.9% |
| Level Of Significance | p=0.05 |
| Method Used | Immunohistochemistry |
| Clinical | No |
| Remarks | Using Prostate cancer as the training set, Liver samples were predicted with 97.7% accuracy, Lung cancer as 94.5% accuracy and Bladder cancer with 88.3% accuracy |
| Clinical Trial Number | NA |
| Degree Of Validity | Validated on independent patient dataset |
| Technical Name | CCNB1: BUB1B: CLDN4: PCLAF: SLC39A6: SOX4: TOP2A: |