| Biomarker ID | 470 |
| PMID | 19633362 |
| Year | 2009 |
| Biomarker | DNA Ploidy - Aneploid |
| Biomarker Basis | Mutation Based |
| Biomolecule | Mutation |
| Source | Tissue |
| Subjects | Humans |
| Regulation | ANUEPLOID: 5 year disease free survival - (49.5% ); 10 year disease free survival - (31.8%) |
| Odds Ratio/Hazard Ratio/Relative Risk | HR: 2.64, 95% CI: (1.32–5.29) |
| Effect on Pathways | NA |
| Experiment | 5 and 10 years disease free survival Vs no survival |
| Type of Biomarker | Prognostic |
| Cohort | 186 patients treated with radical prostatectomy were tested for DNA Ploidy. Of the 186 prostatectomies, 96 were identified as diploid, 61 as tetraploid and 29 as aneuploid. 50 experienced relapse within 60 months, 12 later than 60 months, and 124 did not relapse. |
| Senstivity | NA |
| Specificity | NA |
| AUC | NA |
| Accuracy | NA |
| Level Of Significance | p<0.001 |
| Method Used | DNA ploidy System composed of an Axioplan II brightfield microscope (Zeiss, Germany) equipped with a scanning stage and controller (Prior scientific, UK), a Piezo focusing unit (PI, Ger- many) and a 10 bit CCD camera (Hamamatsu Photonics, Japan), a PCDIG frame card (Correco Imaging, USA) and a 546 nm green filter. |
| Clinical | No |
| Remarks | Multivariate Analysis; Only Anueploid was statistically significant in multivariate Analysis |
| Clinical Trial Number | NA |
| Degree Of Validity | Not validated on independent patient dataset |
| Technical Name | NA |