Biomarker ID | 466 |
PMID | 19542190 |
Year | 2009 |
Biomarker | Prostate Specific Antigen (PSA) |
Biomarker Basis | Concentration Based (ng/ml) |
Biomolecule | Protein |
Source | Serum |
Subjects | Humans |
Regulation | Downregulated after Polyphenon E treatment(7.9%) |
Odds Ratio/Hazard Ratio/Relative Risk | NA |
Effect on Pathways | Pathways include:-ID regulation of gene expression,Prostate cancer,Androgen receptor proteolysis and transcription regulation,Androgen receptor signaling, proteolysis, and transcription regulation,Insulin-like growth factor (IGF) activity regulation by insulin-like growth factor binding proteins (IGFBPs) |
Experiment | Before Vs After Polyphenon E treatment |
Type of Biomarker | Predictive |
Cohort | Twenty-six men with positive prostate biopsies, scheduled for radical prostatectomy were given daily doses of Polyphenon E, to detect the affect of the drug. |
Senstivity | NA |
Specificity | NA |
AUC | NA |
Accuracy | NA |
Level Of Significance | p=0.009 |
Method Used | ELISA |
Clinical | No |
Remarks | NA |
Clinical Trial Number | NA |
Degree Of Validity | Not validated on independent patient dataset |
Technical Name | KLK3 |