| Biomarker ID | 465 |
| PMID | 19542190 |
| Year | 2009 |
| Biomarker | IGF Binding Protein-3 (IGFBP-3) |
| Biomarker Basis | Concentration Based (ng/ml) |
| Biomolecule | Protein |
| Source | Serum |
| Subjects | Humans |
| Regulation | Downregulated after Polyphenon E treatment(11%) |
| Odds Ratio/Hazard Ratio/Relative Risk | NA |
| Effect on Pathways | Pathways Include:-Hypoxia and p53 in the cardiovascular system,Insulin-like growth factor (IGF) activity regulation by insulin-like growth factor binding proteins (IGFBPs),TAp63 pathway,Delta Np63 pathway,Ghrelin-mediated regulation of food intake and energy homeostasis |
| Experiment | Before Vs After Polyphenon E treatment |
| Type of Biomarker | Predictive |
| Cohort | Twenty-six men with positive prostate biopsies, scheduled for radical prostatectomy were given daily doses of Polyphenon E, to detect the affect of the drug. |
| Senstivity | NA |
| Specificity | NA |
| AUC | NA |
| Accuracy | NA |
| Level Of Significance | p=0.024 |
| Method Used | ELISA |
| Clinical | No |
| Remarks | NA |
| Clinical Trial Number | NA |
| Degree Of Validity | Not validated on independent patient dataset |
| Technical Name | IGFBP3 |