| Biomarker ID | 439 |
| PMID | 19283074 |
| Year | 2009 |
| Biomarker | Methylation Status of: Ventral anterior homeobox 1 (VAX1); Homeobox D3 (HOXD3); CAP-GLY domain containing linker protein family (CLIP4); Calcium channel, voltage dependent, T-type, alpha 1G 2.0 subunit (CACNA1G) ; Glycoprotein V (GP5); Somatostatin receptor 1 (SSTR1); Methylthioadenosine phosporylase (MTAP); NK2 homeobox 2 (NKX2-2); Homeobox C11 (HOXC11); Ladybird homeobox 1 (LBX1); Motor neuron and pancreas homeobox 1 (MNX1); Glutamate receptor, metabotropic 1 (GRM1); LIM homeobox 9 (LHX9); Microtubule-associated protein tau (MAPT); Galactosidase, beta 1-like (GLB1L) |
| Biomarker Basis | Methylation Based |
| Biomolecule | Methylation |
| Source | Tissue |
| Subjects | Humans |
| Regulation | Hypermethylated in Progression (PP4): [Ventral anterior homeobox 1 (VAX1) (2.7 fold); Homeobox D3 (HOXD3) (2.3 fold); CAP-GLY domain containing linker protein family (CLIP4) (2.1 fold); Calcium channel, voltage dependent, T-type, alpha 1G 2.0 subunit (CACNA1G) (2.0 fold); Glycoprotein V (GP5) (1.9 fold); Somatostatin receptor 1 (SSTR1) (1.8 fold); Methylthioadenosine phosporylase (MTAP) (1.8 fold); NK2 homeobox 2 (NKX2-2) (1.7 fold); Homeobox C11 (HOXC11) (1.6 fold); Ladybird homeobox 1 (LBX1) (1.6 fold); Motor neuron and pancreas homeobox 1 (MNX1) (1.6 fold); Glutamate receptor, metabotropic 1 (GRM1) (1.6 fold); LIM homeobox 9 (LHX9) (1.6 fold); Microtubule-associated protein tau (MAPT) (1.5 fold); Galactosidase, beta 1-like (GLB1L) (1.5 fold)] |
| Odds Ratio/Hazard Ratio/Relative Risk | NA |
| Effect on Pathways | NA |
| Experiment | Gleason Score 6 (Pure pattern 3) vs Gleason Score 8 (Pure Pattern 4) |
| Type of Biomarker | Prognostic |
| Cohort | 20 fresh frozen PCa tissue samples (10 Gleason score 6 or pure pattern 3 (PP3), and 10 Gleason score 8 or pure pattern 4. 39 PCa samples (20 PP3 and 19 PP4) from patients diagnosed were similarly collected for the validation set. |
| Senstivity | NA |
| Specificity | NA |
| AUC | NA |
| Accuracy | NA |
| Level Of Significance | p<0.05 |
| Method Used | CpG island arrays |
| Clinical | No |
| Remarks | NA |
| Clinical Trial Number | NA |
| Degree Of Validity | Not validated on independent patient dataset |
| Technical Name | Ventral anterior homeobox 1 (VAX1), Homeobox D3 (HOXD3), CAP-GLY domain containing linker protein family (CLIP4), Calcium channel, voltage dependent, T-type, alpha 1G 2.0 subunit (CACNA1G), Glycoprotein V (GP5), Somatostatin receptor 1 (SSTR1), Methylthioadenosine phosporylase (MTAP), NK2 homeobox 2 (NKX2-2), Homeobox C11 (HOXC11), Ladybird homeobox 1 (LBX1), Motor neuron and pancreas homeobox 1 (MNX1), Glutamate receptor, metabotropic 1 (GRM1), LIM homeobox 9 (LHX9), Microtubule-associated protein tau (MAPT), Galactosidase, beta 1-like (GLB1L) |