| Biomarker ID | 438 |
| PMID | 19283074 |
| Year | 2009 |
| Biomarker | Methylation Status of: Chromosome 20 open reading frame 103 (C20orf103); Homeobox D9 (HOXD9); Nuclear receptor subfamily, group A, member 2 (NR5A2); Distal-less homeobox 5 (DLX5); Iroquois homeobox 1 (IRX1); Spastic paraplegia 20 (SPG20); Transcription factor AP-2 alpha (TFAP2A); Wilms tumor 1 (WT1); SIX homeobox 6 (SIX6); Homeobox D4 (HOXD4) ; Transcription factor 7-like 1 (TCF7L1); Sonic hedgehog homolog (SHH); Protocadherin, gamma subfamily C,5 (PCDHG5); Methionine aminopeptidase 1D (MAP1D); Runt-related transcription factor 1 (RUNX1) |
| Biomarker Basis | Methylation Based |
| Biomolecule | Methylation |
| Source | Tissue |
| Subjects | Humans |
| Regulation | Hypermethylated in PCa: [Chromosome 20 open reading frame 103 (C20orf103) (3.7 fold); Homeobox D9 (HOXD9) (3.2 fold); Nuclear receptor subfamily, group A, member 2 (NR5A2) (3.1 fold); Distal-less homeobox 5 (DLX5) (3.7 fold); Iroquois homeobox 1 (IRX1) (3.0 fold); Spastic paraplegia 20 (SPG20) (3.0 fold); Transcription factor AP-2 alpha (TFAP2A) (2.9 fold); Wilms tumor 1 (WT1) (2.9 fold); SIX homeobox 6 (SIX6) (2.8 fold); Homeobox D4 (HOXD4) (2.7 fold) ; Transcription factor 7-like 1 (TCF7L1) (2.6 fold); Sonic hedgehog homolog (SHH) (2.5 fold) ; Protocadherin , gamma subfamily C,5 (PCDHG5) (2.4 fold); Methionine aminopeptidase 1D (MAP1D) (2.3 fold); Runt-related transcription factor 1 (RUNX1) (2.3 fold);] |
| Odds Ratio/Hazard Ratio/Relative Risk | NA |
| Effect on Pathways | NA |
| Experiment | Cancer Vs Non Cancer |
| Type of Biomarker | Diagnostic |
| Cohort | 20 fresh frozen PCa tissue samples (10 Gleason score 6 or pure pattern 3 (PP3), and 10 Gleason score 8 or pure pattern 4. 39 PCa samples (20 PP3 and 19 PP4) from patients diagnosed were similarly collected for the validation set. The reference sample consisted of DNA isolated from lymphocytes of six healthy men age-matched with PCa patients. |
| Senstivity | NA |
| Specificity | NA |
| AUC | NA |
| Accuracy | NA |
| Level Of Significance | p<0.05 |
| Method Used | CpG island arrays |
| Clinical | No |
| Remarks | NA |
| Clinical Trial Number | NA |
| Degree Of Validity | Not validated on independent patient dataset |
| Technical Name | Chromosome 20 open reading frame 103 (C20orf103), Homeobox D9 (HOXD9), Nuclear receptor subfamily, group A, member 2 (NR5A2), Distal-less homeobox 5 (DLX5), Iroquois homeobox 1 (IRX1), Spastic paraplegia 20 (SPG20), Transcription factor AP-2 alpha (TFAP2A), Wilms tumor 1 (WT1), SIX homeobox 6 (SIX6), Homeobox D4 (HOXD4), Transcription factor 7-like 1 (TCF7L1), Sonic hedgehog homolog (SHH), Protocadherin, gamma subfamily C,5 (PCDHG5), Methionine aminopeptidase 1D (MAP1D), Runt-related transcription factor 1 (RUNX1) |