| Biomarker ID | 417 |
| PMID | 19229851 |
| Year | 2009 |
| Biomarker | Transforming growth factor-b1 |
| Biomarker Basis | Expression Based |
| Biomolecule | Protein |
| Source | Plasma |
| Subjects | Humans |
| Regulation | Increased Expression with Biochemical Recurrence |
| Odds Ratio/Hazard Ratio/Relative Risk | Univariate: HR: 1.31; Multivariate: HR: 1.17; |
| Effect on Pathways | Pathways Include:-TGF-beta receptor activation of SMADs,NF-kappaB activation by non-typeable Hemophilus influenzae, Cell cycle: G1/S checkpoint,Syndecan 2 pathway,Signal transduction through IL-1R |
| Experiment | Recurrence Vs No recurrence for 5 years |
| Type of Biomarker | Prognostic |
| Cohort | A cohort of 423 men was used to develop and internally validate the post-operative nomogram for prediction of Biochemical Recurrance. |
| Senstivity | NA |
| Specificity | NA |
| AUC | NA |
| Accuracy | Concordance Index = 85% |
| Level Of Significance | Univariate: p<0.001; Multivariate: p=0.003 |
| Method Used | enzyme immunoassays |
| Clinical | No |
| Remarks | NA |
| Clinical Trial Number | NA |
| Degree Of Validity | Not validated on independent patient dataset |
| Technical Name | TGFB1 |