| Biomarker ID | 403 |
| PMID | 19064574 |
| Year | 2008 |
| Biomarker | Ki-67 |
| Biomarker Basis | Expression Based |
| Biomolecule | Protein |
| Source | Tissue |
| Subjects | Humans |
| Regulation | Downregulated with Flaxseed supplemented Diet [ Control Diet: 3.23 (95% CI: 2.42-3.92), Flaxseed Supplementation: 1.66 (95% CI: 1.13-2.64)] |
| Odds Ratio/Hazard Ratio/Relative Risk | NA |
| Effect on Pathways | Pathways Include:- RANKL regulation of apoptosis and immune response |
| Experiment | Controls Vs Flaxseed Supplementation in Patients with PCa |
| Type of Biomarker | Predictive |
| Cohort | 161 patients having prostate cancer were randomly assigned diets 21 days before prostatectomy. 41 were given control diet (Usual diet), 40 were given Flaxseed supplementation, and 40 were given low fat diet. 40 were given both Low fat and Flaxseed supplementation diet. |
| Senstivity | NA |
| Specificity | NA |
| AUC | NA |
| Accuracy | NA |
| Level Of Significance | p=0.0013 |
| Method Used | Immunochemiluminometric assays |
| Clinical | Yes |
| Remarks | NA |
| Clinical Trial Number | NCT00049309 |
| Degree Of Validity | Not validated on independent patient dataset |
| Technical Name | MKI67 |