| Biomarker ID | 399 |
| PMID | 19047106 |
| Year | 2008 |
| Biomarker | PSA+Surgical Margins+ seminal vesicle invasion+ Gleason Score+CX3CL1+CCL4+IL-15 |
| Biomarker Basis | Concentration Based (ng/mg) |
| Biomolecule | Protein |
| Source | Tissue |
| Subjects | Humans |
| Regulation | Differentially Expressed |
| Odds Ratio/Hazard Ratio/Relative Risk | NA |
| Effect on Pathways | Pathways Include(CCL4):- Selective expression of chemokine receptors during T-cell polarization, Pertussis toxin-insensitive CCR5 signaling in macrophageBinding of chemokines to chemokine receptors, Cytosolic DNA-sensing pathway ,Thymic stromal lymphopoietin (TSLP) pathway;Pathways include (CX3CL1):-Pathways Include:-Binding of chemokines to chemokine receptors,Leptin influence on immune response,TNF-alpha effects on cytokine activity, cell motility, and apoptosis,p53 signaling pathway, Chemokine signaling pathway |
| Experiment | Biochemical Recurrence Vs No Recurrence |
| Type of Biomarker | Prognostic |
| Cohort | 183 patients were taken into the study. 82 patients developed reccurance within 5 years and 98 age matched controls (PCA with no recurrance). |
| Senstivity | 90% |
| Specificity | 72% |
| AUC | 0.877 |
| Accuracy | NA |
| Level Of Significance | NA |
| Method Used | ELISA |
| Clinical | No |
| Remarks | Multivariate Analysis |
| Clinical Trial Number | NA |
| Degree Of Validity | Not validated on independent patient dataset |
| Technical Name | CX3CL1, CCL4, IL15 |