Biomarker ID | 342 |
PMID | 18553995 |
Year | 2008 |
Biomarker | Ras-related protein R-Ras (p23) |
Biomarker Basis | Expression Based |
Biomolecule | Protein |
Source | Tissue |
Subjects | Humans |
Regulation | Downregulated (Mean Ratio: 0.31 ±0.10) |
Odds Ratio/Hazard Ratio/Relative Risk | NA |
Effect on Pathways | Pathways Include:-Activation of NMDA receptor upon glutamate binding and postsynaptic events,Ras family activation regulation,Sema3A-plexin repulsion signaling by inhibiting integrin adhesion,Sema4D in semaphorin signaling,Semaphorin interactions |
Experiment | Prostate cancer Vs Benign Prostatic Hyperplasia |
Type of Biomarker | Diagnostic |
Cohort | 20 patients were chosen for the study. 10 patients with Prostate Cancer and 10 patients with benign prostatic hyperplasia (BPH). |
Senstivity | NA |
Specificity | NA |
AUC | NA |
Accuracy | NA |
Level Of Significance | p≤0.01 |
Method Used | Isobaric tag for relative and absolute quantitation (iTRAQ) , two-dimensional liquid chromatography-tandem mass spectrometry (2DLC-MS/MS) |
Clinical | No |
Remarks | Mean ratio corresponds to the protein reporter ion intensity originating from PCa relative to BPH. Immunohistochemistry was performed on selected genes- PSMA, AMACR, and MUC18 to confirm iTRAQ results |
Clinical Trial Number | NA |
Degree Of Validity | Not validated on independent patient dataset |
Technical Name | RRAS |