Biomarker ID | 318 |
PMID | 18553995 |
Year | 2008 |
Biomarker | Angiotensin-converting enzyme, somatic isoform (precursor) (CD143 antigen) |
Biomarker Basis | Expression Based |
Biomolecule | Protein |
Source | Tissue |
Subjects | Humans |
Regulation | Downregulated (Mean Ratio: 0.32 ±0.09) |
Odds Ratio/Hazard Ratio/Relative Risk | NA |
Effect on Pathways | Pathways Include:-Renin-angiotensin system,ACE inhibitor pathway,Angiotensin-converting enzyme 2 regulation of heart function,RAGE pathway,Dilated cardiomyopathy |
Experiment | Prostate cancer Vs Benign Prostatic Hyperplasia |
Type of Biomarker | Diagnostic |
Cohort | 20 patients were chosen for the study. 10 patients with Prostate Cancer and 10 patients with benign prostatic hyperplasia (BPH). |
Senstivity | NA |
Specificity | NA |
AUC | NA |
Accuracy | NA |
Level Of Significance | p≤0.01 |
Method Used | Isobaric tag for relative and absolute quantitation (iTRAQ) , two-dimensional liquid chromatography-tandem mass spectrometry (2DLC-MS/MS) |
Clinical | No |
Remarks | Mean ratio corresponds to the protein reporter ion intensity originating from PCa relative to BPH. Immunohistochemistry was performed on selected genes- PSMA, AMACR, and MUC18 to confirm iTRAQ results |
Clinical Trial Number | NA |
Degree Of Validity | Not validated on independent patient dataset |
Technical Name | ACE |