| Biomarker ID | 31 |
| PMID | 11926890 |
| Year | 2002 |
| Biomarker | Alpha Methylacyl Coenzyme A Racemase (AMACR) |
| Biomarker Basis | Expression Based |
| Biomolecule | Protein |
| Source | Tissue |
| Subjects | Humans |
| Regulation | Upregulated in Localised Prostate Cancer [Mean expression Value: (Localised Prostate Cancer: 3.2 vs Normal Prostate: 1.3)] |
| Odds Ratio/Hazard Ratio/Relative Risk | NA |
| Effect on Pathways | Pathways Include:-Primary bile acid biosynthesis,Bile acids and bile salt biosynthesis,Peroxisomal lipid metabolism,Bile acid and bile salt biosynthesis via 7-alpha-hydroxycholesterol,Bile acid and bile salt metabolism |
| Experiment | Benign Prostate vs Localised Prostate Cancer |
| Type of Biomarker | Diagnostic |
| Cohort | 342 samples were assessed. Benign prostate (n=108 samples), atrophic prostate (n=26), prostatic intraepithelial neoplasia (n=75), localized prostate cancer (n=116) and metastatic prostate cancer (n=17) |
| Senstivity | 97% |
| Specificity | 100% |
| AUC | NA |
| Accuracy | NA |
| Level Of Significance | p<0.001 |
| Method Used | Immunohistochemistry |
| Clinical | No |
| Remarks | Validated on both Protein and RNA level |
| Clinical Trial Number | NA |
| Degree Of Validity | Validated on independent patient dataset |
| Technical Name | AMACR |